Penta-CIDP Platform for Chronic Inflammatory Demyelination Polyneuropathy     

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Disease Background: Chronic inflammatory demyelinating polyneuropathy is caused by inflammation of nerve roots and peripheral nerves leading to a degeneration of the myelin sheath. Neurons that develop such a pathology display poor transmission of neuronal signals and leads to a loss of nerve fiber. Subsequently, the patients undergo impaired motor function with either weakness or paralysis. The severity of the disease may vary by individuals with a relapse of the condition or steady progress.

 

Details on the Model: Pentagrit zebrafish model of Chronic Inflammatory Demyelination Polyneuropathy is induced by immunization with peripheral nerve homogenate. The model therefore exhibits a pathology of peripheral nerve demyelination with increased protein levels in the CSF. The disease progress with the model exhibiting compromised motor functions and numbness which further progresses to movement impairment with subsequent mortality. Prednisone delays progress of CIDP in zebrafish model with improvement in mortality rates.