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Huntington’s Zebrafish Model ZFHDL

Phenotype and genotype selected mutants are inbred to obtain HTT K32Q -/-

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Assays

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Phenotype Screening and Quantification

  1. Spatial Memory Measure

  2. Fatigue Resistance

  3. Avoidance Learning and Memory

  4. Chorea/Involuntary Jerk Movement

  5. Wall Butt Behavior

  6. Field Test for Distance Travelled

  7. Field Test for Time in Motion

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Relative Gene Expression profile - RT PCR

  8. B3GAT1, Actn2, ADGRG1, TUBB2A, MTCO1P12, Scl45a3, Wt1, Pcdh20

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ELISA

  9. Nfl, HTT, BDNF

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Immunohistochemistry

10. Striatal Neurodegeneration

11. Striatal Activated Microglia

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