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Amyotrophic Lateral Sclerosis Zebrafish Model ZFALL

Phenotype and genotype selected mutants are inbred to obtain TDP-43-/-

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Assays

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Phenotype Screening and Quantification

  1. Field Test for Distance Travelled

  2. Dysphagia Phenotype with constricted GI Tract

  3. % Respiratory Insufficiency Phenotype with Reduced Operculum Activity

  4.  Behavior Response - Aggression and Irritability

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Relative Gene Expression profile - RT PCR

  5. FUS, SPG11, ZNF512B, SS18L1, EWSR1, SOD1, C9ORF72

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ELISA

  6. CRP, pNfH, CHIT, IGF1

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Immunohistochemistry

  7. Number of Motor Neurons per Field

  8. % Colocalized proteins

 9. Custom Markers

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