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Tauopathy Zebrafish Model ZFTAL

Phenotype, genotype selected Mutants are inbred to obtain zebrafish tau with p.SER282X-/-

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Assays

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Phenotype Screening and Quantification

  1. Contextual Fear

  2. New Context For Exploratory Behavior

  3. Mirror Biting Social Behavior

  4. Field Test for Distance Travelled

  5. Field Test for Time in Motion

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Relative Gene Expression profile - RT PCR

  6. Prkca, Mecp2,Strn4, Slc40a1, Pold2, Pcsk2, Krt12, Cers1, Plat

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ELISA

  7. Total Tau, pTau

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Histology

  8. Histological Scoring for Neurodegeneration  

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