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Parkinson's Zebrafish Model ZFPDL

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PINK1 mutants are phenotype, genotype selected and inbred to obtain PINK1-/- larvae which are grafted with exogenous phosphorylated α-Synuclein.

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Assays

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Phenotype Screening and Quantification

  1. Field Test for Distance Travelled

  2. Field Test for Time in Motion

  3. Avoidance Learning and Memory

  4. Motor Co-ordination Latency in Swim Tunnel 

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Relative Gene Expression profile - RT PCR

  5. hif1α, catalase, SOD3, atp1a2a, fech, pax2a, notch1a, Caspase3

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ELISA

  6. Quantitative Reactive Oxygen Species

  7. Total Levels of pGSK3β, PARK7

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Immunohistochemistry

  8. No. of Dopaminergic Neurons per Field

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