Accredited
Pentagrit Discovery Services Platform
1. Dose Response Studies
Phenotype Rescue Plate Assays
Field Test - locomotion activity, Movement Phenotype - Darting, Stereotype, Jerky, Tremor, Social Behavior - Anxiety, Wall Butt, Withdrawal, Depression, Habituation - Sleep, Startle Reflex, Fear Response, Behavior - Pain, Inflammation and Fever etc...
Functional Rescue Assays
Brain Activity, ECG, Thread Mill Cardiac Performance, Bone & Joint Movements, Tumor Volume, Vasculitis etc...
2. Proof of Concept Studies
Biomarker Assays
ELISA/IHC CSF extracts of Total Tau, SERUM, NeFl, IgM,CRP, pNfH, CHIT, IGF1,Nfl, MOG, sIFNAR2,MPO,CXCL1,p53, APC, TEN, Cellular Markers - IHC, PAX-5, CD79a, F4/80, ED2 etc...
Pathological Scoring Assays
Histology Scoring Striatal Microglia, Neurodegeneration, All Pathies, Fecal Calprotectin, Ulceration Score, Tumor, etc...
3. Physiological Response Studies
Serum Profile Assays
Fasting Glucose, Glucose Tolerance, Triglyceride, Cholesterol, CRP, etc...
Blood Profile Assays
Haematology Leukocyte Count, Blood Count, Platelets Marrow and Spleen Samples etc...
4. Mechanisms of Activity (MOA)
Gene Expression RT-PCR
IL-1 IL-6 TNF-α CCL2, MMP3 etc...
5. Safety Studies
Safety Toxicology
Intestine Length, Liver Cirrhosis, Cardiac Hypertrophy
6. Translational Studies
Bioavailability Exposure Assays
Bioavailability Tissue Concentrations vs Time Expore Time and Elimination
Quality of life Measures
Body Weight, Survival, Quality of life score
