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Multiple Sclerosis

MOG Induced

 Phenotype

  • Thread mill fatigue

  • Temperature sensitive pain

  •  Loss of Avoidance Memory

  • Local Field Potential with hyperactive signature

  • Muscle Numbness

  • Reduced distance Travelled

  • Reduce Time in Motion

  • Poor Visual Acuity

Histology

  • Demyelination

  • Oligodendrocyte Degeneration

  • Neuronal Loss

  • Focal inflammatory infiltrates in Meninges

  • Granular mitoses

  • Myelin debris in Cytoplasm

Multiple Sclerosis Research Model

Biomarkers

  • HIT1

  • GPNMB

  • CCL18

  • OLR1

  • CXCR4

  • CCl2

  •  IL-6

  • TREM119

  • PLXDC2

  • Nfl

  • MOG

  • sIFNAR2

  • MPO

  • CXCL1

Ulcerative Colitis

Oxazolone Induced

 Phenotype

  • Frequent Bowel Movement

  • Intestine Length Reduction

  • Abdominal pain with writhing movement or curved phenotype

  • Reduced Food Intake

  • Weight Loss

  • Skin Slough

  • Gait Freezing

  • Reduced movement

  • Fever

Histology

  • Scoring and Staging

  • Scattered infiltrating mononuclear cells (1-2 foci)

  • Severe inflammation with increased vascular density and marked wall thickening

  • Transmural leukocyte infiltration and loss of goblet cell

Ulcerative Colitis Research Model

Biomarkers

  • Fecal calprotectin

  • Fecal lactoferrin

  • Serum CRP

  • Leucine-rich glycoprotein

  • pANCA

  • ESR

  • Anti-OmpC

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