Custom Model Development; Target Identification and Validation

Design a model of choice customized to express a strong and stable phenotype

Single Gene Mutation Model

Single gene mutants that replicate sequential pathophysiology can be fished out from our living library or used from our frozen library of zebrafish models

Multigene disorder and infectious disease model

Multigene disorder disease models are constructed through grafts as in the case of oncology. Metabolic models through dietary intervention, lewy body models through induction of exogenous fibrils in an PINK mutant etc..

Target Identification and Validation

Idenify expression fold difference in model vs wild type; overexpress or delete identified targets