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Target Deconvolution Services

Knockdown, Knockout Models

Pentagrit helps to identify new disease targets by creating accurate models. Zebrafish models are created as knockouts, single basepair mutations, insertional repeats, overexpression, diet and through exogenous agents such as toxins

Expression Profiles

Genes overexpressed / under-expressed in this model can be quantified through PCR and differentially expressed genes in the models can be identified enabling quantification of phenotype response

Target Modulation

Suppression of overexpressed genes and expression of under-expressed genes by employing a vector in the model would validate if the differentially expressed genes could be potential targets

Target Validation

Linkage analysis of identified potential targets with pathways involved in the disease mechanism can be carried out and the mechanisms of target activity with relation to disease progress can be identified

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