Target Deconvolution Services
Knockdown, Knockout Models
Pentagrit helps to identify new disease targets by creating accurate models. Zebrafish models are created as knockouts, single basepair mutations, insertional repeats, overexpression, diet and through exogenous agents such as toxins
Expression Profiles
Genes overexpressed / under-expressed in this model can be quantified through PCR and differentially expressed genes in the models can be identified enabling quantification of phenotype response
Target Modulation
Suppression of overexpressed genes and expression of under-expressed genes by employing a vector in the model would validate if the differentially expressed genes could be potential targets
Target Validation
Linkage analysis of identified potential targets with pathways involved in the disease mechanism can be carried out and the mechanisms of target activity with relation to disease progress can be identified