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Acute Lymphocytic Leukemia
TAL1 overexpression - Ectopic expression, PTEN deletion - Loss of function

Acute Lymphocytic Leukemia

  • Genotype

    TAL1 overexpression, PTEN deletion

  • Mechanism

    TAL1 overexpression - Ectopic expression, PTEN deletion - Loss of function

  • Phenotype

    Locomotor activity, Fatigue, Exploratory activity

  • Biomarker

    Lactate Dehydrogenase, β2-microglobulin

  • Gene Expression Markers

    TAL1, LMO1/2, RUNX1, CD7, NOTCH1, MYC/CCND1, CD34 , BCL2 

  • Physiology Changes

    Anemia, Thrombocytopenia, Lymphoid organ enlargement, Weight loss

  • Histology Grading Endpoint

    Lymphoblasts, Loss of normal lineages, Splenomegaly, Marrow replacement

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