Blogs

Non–small cell lung cancer (NSCLC) is one of the most challenging cancers to treat, especially the KRAS G12C mutation which historically known as undruggable target. In this case, Sotorasib has changed this by showing inhibition against the KRAS G12C mutant protein and making it to stay in an inactive GDP-bound state. This action shuts down downstream MAPK signaling which helps in slowing tumor cell proliferation and activation of apoptosis. Preclinical development of sotoras

Metabolic dysfunction–associated steatohepatitis (MASH) has a long history of therapeutic challenge due hepatic fat accumulation, inflammation and progressive fibrosis. Traditional drug candidates introduced many new problems such as hypoglycemia, LDL elevation and complex drug–drug interactions lead to limiting long term safety use. Resmetirom, a selective thyroid hormone receptor beta (THR-β) agonist has directly enhanced liver specific lipid metabolism without causing any

Insomnia affects millions worldwide, often starts from an over expressive orexin system that keeps the brain in a prolonged wake up cycle. Lemborexant, a dual orexin receptor antagonist, reduces this hyper expression by blocking OX1R and OX2R receptors and promoting natural sleep with reduced sedation. Older therapies potentially caused drowsiness, narcolepsy episodes and some metabolic issues linked to CYP3A4. Clinical sleep trials widely measured EEG and EMG to map brain ac

Antibody therapies need evaluation of safety efficacy in physiological models to gain maximum translation benefit. Towards such, ADCs...

SYNGAP1, a synaptic Ras GTPase activating protein deficiency is associated with severe intellectual disability in humans. Zebrafish...

A number of new drugs for neurodegenerative and inflammatory disease focus on target sites primarily within the brain. With human ED50 at...

Neuroactive Insecticide Bioactivity Testing

There is a need to understand fundamental mechanisms that leads to dysregulation trigger; which eventually leads up to neurodegeneration....

Gene editing primarily focus on threshold of edited protein as an Index of success rate. However in almost all cases, gene editing is met...