Blogs

Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by persistent inflammation of the colon, mucosal ulceration which leads to disrupting the quality of life. Traditional therapies often introduced new risks including bradycardia, macular edema and other metabolic complications highlighting the need for new targeted interventions. Guselkumab, is a monoclonal antibody which was designed to block interleukin-22 (IL-22) driven inflammatory signaling, provides

Non–small cell lung cancer (NSCLC) is one of the most challenging cancers to treat, especially the KRAS G12C mutation which historically known as undruggable target. In this case, Sotorasib has changed this by showing inhibition against the KRAS G12C mutant protein and making it to stay in an inactive GDP-bound state. This action shuts down downstream MAPK signaling which helps in slowing tumor cell proliferation and activation of apoptosis. Preclinical development of sotoras

Metabolic dysfunction–associated steatohepatitis (MASH) has a long history of therapeutic challenge due hepatic fat accumulation, inflammation and progressive fibrosis. Traditional drug candidates introduced many new problems such as hypoglycemia, LDL elevation and complex drug–drug interactions lead to limiting long term safety use. Resmetirom, a selective thyroid hormone receptor beta (THR-β) agonist has directly enhanced liver specific lipid metabolism without causing any

Insomnia affects millions worldwide, often starts from an over expressive orexin system that keeps the brain in a prolonged wake up cycle. Lemborexant, a dual orexin receptor antagonist, reduces this hyper expression by blocking OX1R and OX2R receptors and promoting natural sleep with reduced sedation. Older therapies potentially caused drowsiness, narcolepsy episodes and some metabolic issues linked to CYP3A4. Clinical sleep trials widely measured EEG and EMG to map brain ac

Antibody therapies need evaluation of safety efficacy in physiological models to gain maximum translation benefit. Towards such, ADCs...

SYNGAP1, a synaptic Ras GTPase activating protein deficiency is associated with severe intellectual disability in humans. Zebrafish...

A number of new drugs for neurodegenerative and inflammatory disease focus on target sites primarily within the brain. With human ED50 at...

Neuroactive Insecticide Bioactivity Testing

There is a need to understand fundamental mechanisms that leads to dysregulation trigger; which eventually leads up to neurodegeneration....

Gene editing primarily focus on threshold of edited protein as an Index of success rate. However in almost all cases, gene editing is met...

mRNA therapeutic applications are growing, however at the clinical stage, they are facing a similar failure rate as of small molecules !...

Key Hallmarks of the Assay: Cortical readings from zebrafish ALS models are generated with the similar sensitivity and readouts as in...

Current Clinical Challenges: In progressive Rheumatoid Arthritis (RA) candidates are designed to target inflammatory mediators -...

Fish swim against water current to spawn, feed and to stay within a particular habitat. This natural motion against water current is...

Real word Data points to directions away from monotherapies. From lessons learned, the risk of severe side effects of ppar agonism, such...

Stargardt Disease Pathology Stargardt disease is an autosomal recessive disease caused by mutations in the ABCA4 gene. ABCA4 are...

Spinal Muscular Atrophy - Disease Pathology Spinal Muscular Atrophy (SMA) is a genetic condition where the ubiquitously made protein...

Anxiety Disorder Pathology Anxiety is a neuropsychiatry condition, that mainly affects emotion. Neurotransmitters and hormones such as...

Multiple Sclerosis - Disease Pathology Multiple sclerosis also called as T cell mediated autoimmune disease, is a condition where the...

Type II Diabetes - Disease Pathology Type II Diabetes is a condition that arises due to an environment of dysregulated glucose and fat...