Pharmacology Studies in Rare Diseases

  • Dose Response Toxicity Curves

Acute Toxicity and Chronic Toxicity assessments include  Necropsy, Pathology, Chemistry, Molecular Profile, ECG, Organ Weight, Body Weight, Blood Profile, Skin profile and Survival Curves

  • Vital Organ Toxicology Studies

Assessments of Cardiotoxicity, Hepatotoxicity, Nephrotoxicity, Neurotoxicity and Dermal Toxicity

  • Development Toxicity and Teratotoxicity

Assessments of Structural abnormality, altered growth, functional deficits

  • Reproductive Toxicity

Assessments during fertility,reproduction,prenatal development, postnatal development

Bio-available Routes of Administration - Oral Diet, Intravenous, Intraperitoneal, Intramuscular,Intrathecal,Subcutaneous, Water Dissolution

 

  • Cardiovascular ModelsDiet Induced and Knockouts 

    Hypertension, Cardiac Hypertrophy,                                                Haemoglobinopathy, Thrombosis and Myocardial Infarction 

 

  • Metabolic - Diet Induced and Knockouts

   NASH, Obesity, Type II Diabetes. Type I                                   Diabetes, Liver Cirrhosis and Renal Failure

  • Tumor - Xenograft and PDX Models

   Skin Tumor, Lung Tumor, Intestine Tumor and
   Liver Tumor

  • Infectious Models - Infectious Agent Induced

    Dengue, Malaria, Meningitosis, Chikungunya

  • Custom Models

     Medical Implants, Anxiety, Memory, Pain, Infertility

Genetic  (knockout or altered gene) Models of Pentagrit carry the genetic pattern of human disease. Our Zebrafish models therefore replicate the pathophysiology and biomarker levels as observed in humans. 


Safety and Toxicology Studies

 

Acute Toxicity and Chronic Toxicity assessments include  Necropsy, Pathology, Chemistry, Molecular Profile, ECG, Organ Weight, Body Weight, Blood Profile, Skin profile and Survival Curves

 

Assessments of Cardiotoxicity, Hepatotoxicity, Nephrotoxicity, Neurotoxicity and Dermal Toxicity

Assessments of Structural abnormality, altered growth, functional deficits

Assessments during fertility,reproduction,prenatal development, postnatal development

Bio-available Routes of Administration - Oral Diet, Intravenous, Intraperitoneal, Intramuscular,Intrathecal,Subcutaneous, Water Dissolution

Pharmacology Studies in Common Diseases

 

  Hypertension, Cardiac Hypertrophy,                                                Haemoglobinopathy, Thrombosis and Myocardial Infarction 

 

 

 

 

 NASH, Obesity, Type II Diabetes. Type I                                   Diabetes, Liver Cirrhosis and Renal Failure

  

 

Skin Tumor, Lung Tumor, Intestine Tumor and  Liver Tumor

   

Dengue, Malaria, Meningitosis, Chikungunya

 

 

 Medical Implants, Anxiety, Memory, Pain, Infertility

Genetic  (knockout or altered gene) Models of Pentagrit carry the genetic pattern of human disease. Our Zebrafish models therefore replicate the pathophysiology and biomarker levels as observed in humans. 

    Amyotrophic lateral sclerosis, Spinal Muscular Atrophy, Multiple      Sclerosis,Dyskinesia,Huntingtons Disease,
    Batten Disease,CDKL5 Deficiency Disorder,Ataxia,Amyloidosis,
    Transthyretin familial amyloid polyneuropathy,Chronic                      Inflammatory Demyelination Polyneuropathy

     

Castleman Disease,Telangiectasia, X linked Severe combined        Immunodeficiency,Hemophilia,Sickle Cell Anemia

   

Mucopolysaccharidoses,Hepatic porphyra,Amyloid                         Cardiomyopathy,Dilated Cardiomyopathy,Acute vaso-occlusive       crises,Focal Segmental Glomerulosclerosis

   

Beckwith-Wiedemann Syndrome,Progeria,Fibrodysplasia-              ossificans progressiva, Vici Syndrome,Gaucher                              disease,Duchenne Muscular Dystrophy,
Kabuki Syndrome Research,Achondroplasia, Fragile X syndrome

   

Paget’s disease, Idiopathic pulmonary fibrosis

Bio-available Routes of Administration - Oral Diet, Intravenous, Intraperitoneal, Intramuscular,Intrathecal,Subcutaneous, Water Dissolution

  • Adult Zebrafish are exposed to chemical mutagen to create random point mutations in progeny

  •  Genotype screens are performed to identify  progeny fish carrying a point mutation in genes associated with the disease susceptibility

  • Phenotype screens are performed to further grade and experimental groups are created

  • Outcomes are measured from 60 subjects with a genetic variation that resemble human susceptible genetic pool for the disease