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Zebrafish as a Model Organism

Pentagrit CRO leverages the zebrafish model for comprehensive pharmacokinetic (PK) analysis, providing a robust platform for evaluating drug absorption, distribution, metabolism, and excretion (ADME). Zebrafish offer a unique combination of rapid development, genetic similarity to humans, and transparency, allowing for real-time imaging and detailed pharmacokinetic profiling. With a dedicated focus on high-throughput screening and advanced analytical methods, Pentagrit delivers reliable PK data essential for preclinical drug development.

Repeat Time points from same Animal

Drug distribution across plasma, tissue and body fluids over time

Plasma_Tissue

Our Services

1

Dosing Route

  • Oral Solid Pellets / Coated Pellets / liquids / Emulsions

  • Intramuscular

  • Subcutaneous

  • Intraperitoneal

  • Intravitreal

  • Intrathecal injection

  • intracranial

  • Intranasal

  • Intra-articular

  • Water Dissolution

2

Analyte Sources

  • Blood - Repeat measure from the same animal through dorsal aorta draw

  • CSF

  • Organs

  • Regions of organs lobes, ventricles, Cortex, Chambers

  • Regenerative Tissue

  • Thymus, Spleen and Kidney

  • Swim Water

3

PK Assessments

  • Area Under the Curve

  • Drug concentration vs time plot

  • Time to peak drug concentration             

  • Peak serum concentration 

  • Biological half-life

  • Volume Distribution

  • Steady state volume of distribution,

  • Clearance

Examining Blood Sample

Zebrafish provide a genetically relevant model for pharmacokinetic studies. Their rapid development, transparency, and genetic similarity to humans allow for real-time imaging and dynamic assessment of drug distribution. Additionally, their small size enables high-throughput screening with minimal compound usage, making zebrafish an ideal model for early-stage pharmacokinetic profiling. Pentagrit’s expertise in zebrafish models ensures robust, reproducible PK data, accelerating drug discovery timelines.

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