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28 Myotonic Dystrophy - DM1_edited.jpg

 Zebrafish Model of Type II Diabetes ZFD2A

Zebrafish are fed with high fat high cholesterol diet for 6 weeks.

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Assays

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Phenotype Screening and Serum Biochemistry

  1. Fasting Glucose mg/dl

  2. Glucose Fed mg/dl  (OGTT after 30 minutes)

  3. Body weight(g) 

  4. ECG ( P value amplitude)

  5. Triglycerides (mg/dl)

  6. Total Cholesterol (mg/dl)

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Relative Gene Expression profile - RT PCR

7. RT PCR NF KB Expression Profile 

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ELISA

 8. Custom

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Histology

9. No of Shrunken Islets - Pancreas Histology

10. Wound Healing Rate (Blastema formation in days)

11. Numbness - Aversive temperature tolerance

12. Retinopathy  - Histology No of Necrotic cells per 100 cells

13. Nephropathy - Histology No of Necrotic cells per 100 cells

14. Neuropathy - Histology No of Necrotic cells per 100 cells

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