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1. Dose Response Studies

Phenotype Rescue Plate Assays

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  • Field Test - locomotion activity,

  • Movement Phenotype - Darting, Stereotype, Jerky, Tremor,

  • Social Behavior - Anxiety, Wall Butt, Withdrawal, Depression,

  • Habituation - Sleep, Startle Reflex, Fear Response,

  • Behavior - Pain, Inflammation and Fever etc...

     Functional Rescue Assays

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  • Brain Activity,

  • ECG, Thread Mill Cardiac Performance,

  • Bone & Joint Movements,

  • Tumor Volume,

  • Vasculitis etc...

2. Proof of Concept Studies

Biomarker Assays

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  • ELISA/IHC

  • CSF extracts of Total Tau, etc...

  • Serum Markers - NeFl, IgM,CRP, pNfH, CHIT, IGF1,Nfl,

  • MOG, sIFNAR2,MPO,CXCL1,p53, APC, TEN, 

  • Cellular Markers  -  PAX-5, CD79a, F4/80, ED2 etc...

  Pathological Scoring Assays

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  • Histology Scoring

  • Striatal Microglia, Neurodegeneration, All Pathies,

  • Liver Score

  • Ulceration Score, 

  • Tumor, etc...

3. Serum Profile Assays

Physiological Response Studies

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  • Fasting Glucose, 

  • Glucose Tolerance, Triglyceride, 

  • Cholesterol, 

  • CRP,  etc...

 Hematology

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  • Leukocyte Count, 

  • Blood Count, Platelets

  • Marrow and Spleen Samples etc...

4. Mechanisms of Activity and Exposure Studies

Gene Expression RT-PCR Analysis

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  • IL-1 IL-6 TNF-α CCL2, MMP3 etc...

Bioavailability Exposure Assays 

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  • Bioavailability

  • Tissue Concentrations vs Time

  • Exposure Time and Elimination

5. Safety/Toxicology

 LD50 Identification

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  • Intestine Length, Liver Cirrhosis,

  • Cardiac Hypertrophy, 

  • Organ Toxicity

  • Systemic Toxicology

Quality of life Measure

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  • Body Weight

  • Survival

  • Quality of life score

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