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Pentagrit Discovery Services Platform

1. Dose Response Studies

Phenotype Rescue Plate Assays

Field Test - locomotion activity, Movement Phenotype - Darting, Stereotype, Jerky, Tremor, Social Behavior - Anxiety, Wall Butt, Withdrawal, Depression, Habituation - Sleep, Startle Reflex, Fear Response, Behavior - Pain, Inflammation and Fever etc...


     Functional Rescue Assays

Brain Activity, ECG, Thread Mill Cardiac Performance, Bone & Joint Movements, Tumor Volume, Vasculitis etc...

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2. Proof of Concept Studies

Biomarker Assays

ELISA/IHC CSF extracts of Total Tau, SERUM, NeFl, IgM,CRP, pNfH, CHIT, IGF1,Nfl, MOG, sIFNAR2,MPO,CXCL1,p53, APC, TEN, Cellular Markers - PAX-5, CD79a, F4/80, ED2 etc...


  Pathological Scoring Assays

Histology Scoring Striatal Microglia, Neurodegeneration, All Pathies, Liver Score Ulceration Score, Tumor, etc...

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3. Physiological Response Studies

Serum Profile Assays

Fasting Glucose, Glucose Tolerance, Triglyceride, Cholesterol, CRP, etc...

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Blood Profile Assays

Haematology Leukocyte Count, Blood Count, Platelets Marrow and Spleen Samples etc...


4. Mechanisms of Activity (MOA) 

Gene Expression RT-PCR

IL-1 IL-6 TNF-α CCL2, MMP3 etc...

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5. Safety Studies

Safety Toxicology

Intestine Length, Liver Cirrhosis, Cardiac Hypertrophy, Organ Toxicity Sytemic Toxicology


6. Translational Studies

Bioavailability Exposure Assays 

Bioavailability Tissue Concentrations vs Time Expore Time and Elimination

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Quality of life Measures

Body Weight, Survival, Quality of life score

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