Discovery Solutions | Pentagrit Zebrafish CRO

PHARMACOKINETICS

Biodistribution - Tissue, Fluids

Routes of Administration

Oral solid, oral liquid, I.P, I.V, intrathecal, intracranial, sub-cutaneous and water dissolution

Time Course - Cmax, k, t1/2 elimination, cl, VD and AUC

Genetic - Toxic Gain of Function, Site Specific Mutants

Knockouts, Knock-in

Inflammatory - SCID Zebrafish,

Xenotransplants - Solid Tumour, CML

Systemic Toxicity - Organ necropsy, hERG, Endocrine, Gene editing tox

Routine Toxicity: OECD Embryo Tests Angiogenesis, Hepatoxicity

Behaviour Toxicity - Cognitive Assessments

Phenotype Rescue - Behaviours, Disease Function

Biomarkers - Gene Expression, Protein

Reference - Standard Drug

Pathology Grading - H&E Stains

IHC Biomarkers - Target Protein Levels

Disease Progress Staging - Drug Treatment Effects

Neural Network Based - Data sets for ML from multi environmental response

Multi Functional - Digital data source at 1/1000th second frequency from three axis of sources

ML Volumes - Over 3 million data point per plot

Model Induction and Dosing - Models dosed with your dilutions of interest.

Continuous Monitoring - Monitor animals through web

Sample Collection and Dispatch: Serum, Tissue, CSF collected at time points and dispatched in dry ice with model background data.