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 Zebrafish Model of NASH ZFNAA

Larvae are fed with very high fat and high carb diet for a period of time

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Assays

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Phenotype Screening

  1. Liver Histology Scores (Steatosis, Inflammation, Ballooning, Cirrhosis)

  2. Obesity - BMI Score

  3. Elevated ST segment - Cardiomyopathy

  4. Late Stage gut dysfunction

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Relative Gene Expression profile - RT PCR

5. Bcl, IL-6, IL-1β, TNFα, and IFNγ Expression Fold Change

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ELISA and Serum Biochemistry

6.Serum Insulin Levels

7.ROS Levels

8. Serum Fatty Acid, Triglycerides, Total cholesterol, ALT, AST, GGT, Fasting Glucose

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Immunohistochemistry

9.Hepatic Stellate Cell Differentiation and Fibrogenesis progress

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