MLL-AF9 - Toxic gain function, Flt3-ITD - Toxic gain function, PDX - Show increased expression of anti-apoptotic proteins
Acute Myeloid Leukemia
Genotype
MLL-AF9, Flt3-ITD, PDX
Mechanism
MLL-AF9 - Toxic gain function, Flt3-ITD - Toxic gain function, PDX - Show increased expression of anti-apoptotic proteins
Phenotype
Locomotor activity, Fatigue, Weakness
Biomarker
Lactate Dehydrogenase
Gene Expression Markers
CD45, CD33, CD13, KI67, MYC, CCND1
Physiology Changes
Weight loss, Anemia, Thrombocytopenia, Splenomegaly / hepatomegaly, Tumor burden
Histology Grading Endpoint
Increased blast population, Rapid marrow replacement, Spleen and liver infiltration