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Addiction
Acute Alcohol Exposure - induces rapid genetic regulation changes, Opiod receptor KO - Loss of function, Dopamine receptor D2 KO - Loss of function

Addiction

  • Genotype

    Acute Alcohol Exposure, Opioid receptor KO, Dopamine receptor D2 KO

  • Mechanism

    Acute Alcohol Exposure - induces rapid genetic regulation changes, Opiod receptor KO - Loss of function, Dopamine receptor D2 KO - Loss of function

  • Phenotype

    Locomotor activity, Cued Learning, Reward associated learning, Tremors, Anxiety, Seizures, Impulsivity, Cognitive impairment

  • Biomarker

    β-Endorphin, Dopamine, MDA, Cortisol, ALT, AST, NfL

  • Gene Expression Markers

     DRD2, TH, SERT, HTR1A, OPRM1, PENK

  • Physiology Changes

    EEG - Delta band activity, Epileptiform activity, REM sleep

  • Histology Grading Endpoint

    Neuronal loss, Apoptosis, Demyelination

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