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Age-related Macular Degeneration
Loss of Function

Age-related Macular Degeneration

  • Genotype

    Sen57wrn

  • Mechanism

    Loss of Function

  • Phenotype

    Visual motor response, Optokinetic response, Optomotor response, Contrast Sensitivity Assay, Startle Response, Varying light response,Aging-Associated Locomotor Decline

  • Biomarker

    VEGF-A,Rhodopsin, Angiopoietin-2, RPE65 protein, MMP-9, C3

  • Gene Expression Markers

    nrf2, sod1, hif1α, p62, apoe, opn1lw, bcl-2

  • Physiology Changes

    ERG - a-wave amplitude, b-wave amplitude, High-frequency stimulation 

  • Histology Grading Endpoint

    RPE loss and atrophy, Prominent drusen accumulation, ONL thinning, Photoreceptor loss, Early neovascular structures

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