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Aggression
Tph2 - Loss of function, Ar KO - Loss of function, Pgr KO - Loss of function

Aggression

  • Genotype

    Tph2, Ar KO, Pgr KO

  • Mechanism

    Tph2 - Loss of function, Ar KO - Loss of function, Pgr KO - Loss of function

  • Phenotype

    Aggression, Impulsivity, Anxiety, Social isolation, Dominance behavior

  • Biomarker

    CRP, Vasopressin, Testosterone, Cortisol

  • Gene Expression Markers

    c-Fos, DRD1, TH, TPH2, HTR1A

  • Physiology Changes

    EEG - Amplitude variability, Reduced slow wave sleep

  • Histology Grading Endpoint

    Neuronal Loss, Microglial activation, Dendritic spine reduction

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