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Agitation
APP23 - Toxic gain function, DAT KO - Loss of function, PTZ - chemical convulsant and GABA receptor antagonist, Caffeine - adenosine receptor antagonist

Agitation

  • Genotype

    APP23, DAT KO, PTZ, Caffeine

  • Mechanism

    APP23 - Toxic gain function, DAT KO - Loss of function, PTZ - chemical convulsant and GABA receptor antagonist, Caffeine - adenosine receptor antagonist

  • Phenotype

    Hyperlocomotion, Repetitive behavior, Anxiety, Seizures, Aggression, Social isolation,Sleep disorder

  • Biomarker

    Dopamine, Glutamate, GABA, Aβ40,BDNF

  • Gene Expression Markers

    DAT, DRD1, SCN1A, APP, BACE1, c-Fos

  • Physiology Changes

    Heart Rate , EEG - Epileptiform discharges, Reduced slow wave sleep

  • Histology Grading Endpoint

    Neuronal loss, Amyloid plaque deposition, Astrogliosis

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