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Alpha-1 Antitrypsin Deficiency
Loss of function

Alpha-1 Antitrypsin Deficiency

  • Genotype

    Serpina1a Knockout

  • Mechanism

    Loss of function

  • Phenotype

    Locomotor activity, Fatigue, Endurance, Anxiety

  • Biomarker

    Alpha-1 antitrypsin, MMP 9, Surfactant proteins, Fibronectin, ALT, AST

  • Gene Expression Markers

    IL 10, muc2, casp3, TNF-α, IL-1β, sox9, cdx2, PEPT1

  • Physiology Changes

    Lethargy, Dyspnea, Hypoxia tolerance, Respiratory rate, Gas exchange efficiency, Inflammation, Liver function

  • Histology Grading Endpoint

    Enlarged airspaces, Reduced gill aerocytes density, Neutrophils and macrophages, Airway wall thickening, Cellular stress, Fibrosis

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