APP - Missense mutation and PS - Knockout
Alzheimer's disease
Genotype
APP(V717L)/PS
Mechanism
APP - Missense mutation and PS - Knockout
Phenotype
Conditional Learning, Motor coordination, Social isolation, Depression, Aggression
Biomarker
Ab 40/42 ratio, GFAP, NfL, pTau 217
Gene Expression Markers
APP, BACE1, MAPT, SYP, TNF, SOD1
Physiology Changes
EEG - Long Term potentiation amplitude (LTP)
Histology Grading Endpoint
Amyloid plaque deposition and Neuronal loss