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Anxiety
Adra2a Knock-out - loss of function, FMR1 - Loss of function, ube3a - Loss of function

Anxiety

  • Genotype

    Adra2a Knock-out, FMR1, ube3a

  • Mechanism

    Adra2a Knock-out - loss of function, FMR1 - Loss of function, ube3a - Loss of function

  • Phenotype

    Anxiety, Hyperactivity, Thigmotaxis, Social isolation, Dark/light preference test, Stress response, Repetitive behavior

  • Biomarker

    Cortisol, Norepinephrine, GABA, CRP

  • Gene Expression Markers

    FMR1, UBE3A, PSD95, c-Fos, Arc, CRH, NR3C1

  • Physiology Changes

    EEG - Gamma oscillations, Event related potential, Slow wave sleep 

  • Histology Grading Endpoint

    Reduced dendtritic spine and Neuronal density, Astrocyte activation, Synaptic loss, Axonal disruption

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