Ovalbumin Induction - induces Th2-driven immune activation
Asthma
Genotype
Ovalbumin Induction
Mechanism
Ovalbumin Induction - induces Th2-driven immune activation
Phenotype
Activity intolerance, Locomotor activity, Fatigue
Biomarker
Total IgE, Fibronectin,CRP
Gene Expression Markers
IL 4, IL 5, IL 6, FCER2, TNF-α, ccr3, muc5b, hif1a, nrf2
Physiology Changes
Lethargy, Dyspnea, Hypoxia tolerance, Respiratory rate, Gas exchange efficiency, Inflammation
Histology Grading Endpoint
Predominantly eosinophils, lymphocytes, Increased goblet cells in airway epithelium, Epithelial shedding, Loss of ciliated cells, Increased vascular permeability