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Attention Deficit Hyperactivity Disorder (ADHD)
DAT - Toxxic gain function, NURRI - Loss of function, GITI - Loss of function

Attention Deficit Hyperactivity Disorder (ADHD)

  • Genotype

    DAT, NURRI, GITI

  • Mechanism

    DAT - Toxic gain function, NURRI - Loss of function, GITI - Loss of function

  • Phenotype

    Hyperactivity, Impulsivity, Cognitive impairment, Delayed response, Attention deficits, Spatial Learning, Anxiety

  • Biomarker

    Norepinephrine, Dopamine, Cortisol

  • Gene Expression Markers

    NURR1, NET, DBH, DAT, TH, DRD1/2

  • Physiology Changes

    EEG - Theta activity, Slow wave dominance, Theta/Beta ratio

  • Histology Grading Endpoint

    Reduced neuronal density and Altered dendritic branching

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