Adenine, folic acid - pharmacological agents used to induce renal injury, fat1 -/- - Loss of function
Chronic Kidney Disease
Genotype
adenine, folic acid, fat1 -/-
Mechanism
Adenine, folic acid - pharmacological agents used to induce renal injury, fat1 -/- - Loss of function
Phenotype
Locomotor activity, Anxiety, Thigmotaxis, Cognitive deficits, Touch evoke response, Paralysis, Social isolation
Biomarker
Creatinine, Blood Urea Nitrogen (BUN), Albumin, NGAL
Gene Expression Markers
tgfβ1, col1a1, fn1, bax, bcl2, caspase-3, nrf2, sod1, gpx1, nphs1
Physiology Changes
Lethargy, Electrolyte imbalance, Oxidative stress
Histology Grading Endpoint
Tubular epithelial necrosis, Glomerular damage, Inflammatory cell infiltration, Interstitial fibrosis