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Chronic Myeloid Leukemia
BCR-ABL - Toxic gain function

Chronic Myeloid Leukemia

  • Genotype

    BCR-ABL

  • Mechanism

    BCR-ABL - Toxic gain function

  • Phenotype

    Hypoactivity, Fatigue, Weight loss, Reduced feeding

  • Biomarker

    Lactate Dehydrogenase, β2-microglobulin

  • Gene Expression Markers

    STAT5A / STAT5B, CD34, KI67, MYC, CCND1

  • Physiology Changes

    Leukocytosis, Anemia, Bone marrow infiltration, Cachexia

  • Histology Grading Endpoint

    Granulocytic hyperplasia, Marrow hypercellularity, Splenomegaly

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