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Colorectal (Gastrointestinal) Cancer
Azoxymethane + Dextran Sulfate Sodium - Potent carcinogen and Chronic inflammation, Apc - Loss of function

Colorectal (Gastrointestinal) Cancer

  • Genotype

    Azoxymethane + Dextran Sulfate Sodium, Apc

  • Mechanism

    Azoxymethane + Dextran Sulfate Sodium - Potent carcinogen and Chronic inflammation, Apc - Loss of function

  • Phenotype

    Locomotor activity, Hunched posture, Fatigue

  • Biomarker

    Lactate Dehydrogenase, CRP, Occludin

  • Gene Expression Markers

    APC , β-catenin , IL-6, COX-2 , KI67 , MYC/CCND1, MMP2, VIM , CDH1 , ZO-1

  • Physiology Changes

    Intestinal permeability, Diarrhea, Tumor formation

  • Histology Grading Endpoint

    Epithelial dysplasia, Tumor infiltration, Loss of normal mucosa

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