Autosomal recessive - Loss of Function
Parkinson's disease
Genotype
Pink 1
Mutation Type/Mechanism
Missense Point Mutation - Toxic gain Function
Phenotype
Tremor, Aggression, Spatial Learning, Associative Learning, Depression
Biomarker
GFAP, Orexin
Gene Expression Markers
TH, DAT, PRKN, LC3B, TNF,
Physiology Changes
Postural Deviation, Gait Capability
Histology Grading Endpoint
Dopaminergic neuronal loss