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Corticobasal Degeneration
Toxic gain function

Corticobasal Degeneration

  • Genotype

    4R tau

  • Mechanism

    Toxic gain function

  • Phenotype

    Motor dysfunction, Motor coordination, Muscle rigidity, Cognitive dysfunction, Anxiety, Social isolation

  • Biomarker

    Total tau, P tau, NfL, GFAP, miR-132

  • Gene Expression Markers

    CDK5, MAP2, DLG4, BAX, BCL2, TNF-α, CD68

  • Physiology Changes

    Bradykinesia, Dystonia, EEG - Irregular spike patterns, Impaired long-term potentiation, Altered beta and gamma oscillations, Altered long-term depression

  • Histology Grading Endpoint

    Accumulation of hyperphosphorylated tau, Neurofibrillary tangles, Loss of neurons in cortex, Increased astrocytosis, Myelin loss, Enlarged neurons

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