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Crohn's Diseases
TNBS - haptenizing agent that causes Th1/Th17 mediated transmural inflammation, uhrf1 - Loss of function

Crohn's Diseases

  • Genotype

    TNBS, uhrf1

  • Mechanism

    TNBS - haptenizing agent that causes Th1/Th17 mediated transmural inflammation, uhrf1 - Loss of function

  • Phenotype

    Locomotor activity, Feeding behavior, Anxiety, Fatigue, Stress response, Irritability

  • Biomarker

    CRP, SAA, Total protein, Ferritin, MMP-9

  • Gene Expression Markers

    TNF-α, IL-6, IFN-γ, IL-17, cxcl10, cldn1, dnmt1, nrf2, crh

  • Physiology Changes

    Lethargy, Weight loss, Altered posture, Defecation, Gut permeability, Shortened colon, Enlarged lymph nodes

  • Histology Grading Endpoint

    Mucosal inflammation, Epithelial disruption, Deep ulcers, Pronounced fibrosis and Structural distortion

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