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Cystic Fibrosis
Loss of function

Cystic Fibrosis

  • Genotype

    Cftr KO

  • Mechanism

    Loss of function

  • Phenotype

    Locomotor activity, Feeding behavior, Anxiety, Exploratory behavior, Erratic swimming, Fatigue

  • Biomarker

    Serum Amyloid A, Neutrophil elastase, CFTR protein, Surfactant proteins, Albumin, Procalcitonin

  • Gene Expression Markers

    slc26a3, aqp1,aqp3, TNF-α, IL-6, tlr2, tlr4, myd88, nrf2, casp3

  • Physiology Changes

    Lethargy, Osmoregulation, Delayed growth, Rapid opercular/gill movements, Reduced gas exchange capacity

  • Histology Grading Endpoint

    Epithelial thickening, Loss of ciliated cells, Enlarged mucus glands, Neutrophil-dominant infiltration, Increased vascular density, Extensive fibrosis

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