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Diabetic Kidney Disease
Glucose immersion - induces metabolic memory and damage to the pronephros, including basement membrane thickening and proteinuria , pdx1 KO - Loss of function

Diabetic Kidney Disease

  • Genotype

    Glucose immersion, pdx1 KO

  • Mechanism

    Glucose immersion - induces metabolic memory and damage to the pronephros, including basement membrane thickening and proteinuria , pdx1 KO - Loss of function

  • Phenotype

    Locomotor activity, Fatigue, Exploratory activity, Touch evoke response, Anxiety

  • Biomarker

    Glucose, Blood Urea Nitrogen, Insulin, NGAL

  • Gene Expression Markers

    pdx1, glut2, nrf2, sod1, gpx1, il1β, tnfα

  • Physiology Changes

    Hyperglycemia, Oxidative stress, Fibrosis

  • Histology Grading Endpoint

    Glomerular enlargement, Tubular epithelial degeneration, Interstitial fibrosis, Inflammatory cell infiltration

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