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Diabetic Macular Edema
STZ-Induction - inducing cytotoxicity to pancreatic 
β-cells via DNA alkylation

Diabetic Macular Edema

  • Genotype

    STZ-Induction

  • Mechanism

    STZ-Induction - inducing cytotoxicity to pancreatic 
    β-cells via DNA alkylation

  • Phenotype

    Visual Motor Response, Optokinetic Response, Optomotor Response, Contrast Sensitivity Assay, Startle Response, Prey Capture Assay

  • Biomarker

    bdnf, GFAP, MMP-9, ICAM-1

  • Gene Expression Markers

    vegfa, vegfr2, angpt2, ocln, vcam-1

  • Physiology Changes

    ERG - a-wave amplitude, b-wave amplitude, High-frequency stimulus, Retinal edema

  • Histology Grading Endpoint

    Severe retinal thickening, Large confluent cystic spaces, Vascular leakage, Marked pericyte loss and capillary degeneration, Inflammatory infiltration

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