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Duchenne Muscular Dystrophy
dmd KO - Loss of Function

Duchenne Muscular Dystrophy

  • Genotype

    dmd KO

  • Mechanism

    Rb1 and Rbl1 - Loss of function

  • Phenotype

    Locomotor activity, Fatigue, Muscle weakness, Motor coordination, Escape response

  • Biomarker

    Creatine Kinase, AST, ALT

  • Gene Expression Markers

    DMD , UTRN , MYOD, TNF-α, TGF-β1, Caspase-3 , BCL2 , SOD1, ATP2A1

  • Physiology Changes

    Abnormal body curvature, Energy metabolism impaired,Cardiomyopathy

  • Histology Grading Endpoint

    Fiber size variability, Inflammatory cell infiltration, fibrosis, Adipose tissue accumulation

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