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Dyslipidemia
Loss of Function

Dyslipidemia

  • Genotype

    ldlr KO, Apo2 KO

  • Mechanism

    Loss of Function

  • Phenotype

    Locomotor activity, Darting behavior, Anxiety, Fatigue, Touch evoke response

  • Biomarker

    Total cholesterol, LDL, HDL, Free fatty acides, Triglycerides

  • Gene Expression Markers

    ldlr, apoa2, apob, apoe, pparα, cpt1a, nrf2, sod1, gpx1

  • Physiology Changes

    Lipid accumulation, Oxidative stress, Liver enlargement

  • Histology Grading Endpoint

    Hepatic steatosis, Vacuolated hepatocytes, Fibrosis, Inflammatory cell infiltration

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