Ovalbumin Induction - leads to pathological activation of immune cells (eosinophils, Th2 cells, basophils) and fibroblasts
Eosinophilic Esophagitis
Genotype
Ovalbumin Induction
Mechanism
Ovalbumin Induction - leads to pathological activation of immune cells (eosinophils, Th2 cells, basophils) and fibroblasts
Phenotype
Feeding behavior, Fatigue, Swallowing dysfunction, Anxiety, Pain, Hypersensitivity
Biomarker
Eosinophil counts, Periostin, SAA, CRP
Gene Expression Markers
IL-4, IL 5, IL 13, TNF-α, cldn1, nrf2
Physiology Changes
Body weight, Lethargy, Increased epithelial permeability, Inflammation, Edema
Histology Grading Endpoint
Dense eosinophils, Mixed immune cells, Loss of epithelial cohesion, Epithelial damage, Increased vascularity, Tissue injury markers