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Epilepsy
Scn1a - Loss of function, Syngap1 - Loss of function, Pentylenetetrazol -By blocking GABA-mediated inhibition, it increases neuronal excitation

Epilepsy

  • Genotype

    Scn1a, Syngap1, Pentylenetetrazol (PTZ)

  • Mechanism

    Scn1a - Loss of function, Syngap1 - Loss of function, Pentylenetetrazol -By blocking GABA-mediated inhibition, it increases neuronal excitation

  • Phenotype

    Locomotor activity, Erratic swimming, Episodic seizures, Cognitive impairment, Muscle cramps

  • Biomarker

    GFAP, Glutamate, MDA, NSE

  • Gene Expression Markers

    PSD-95, GAD1 / GAD67, GABRA1, c-Fos, Egr1

  • Physiology Changes

    EEG - Seizure Activity - High-amplitude spike-and-wave discharges (SWDs), Burst activity - Paroxysmal burst firing and Alpha/Beta activity

  • Histology Grading Endpoint

    Neuronal loss, Hippocampal damage, Reduced synaptic density

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