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Focal Segmental Glomerulosclerosis
Metronidazole - causes massive proteinuria, nphs1 Knockdown - Loss of function

Focal Segmental Glomerulosclerosis

  • Genotype

    Metronidazole, nphs1 Knockdown

  • Mechanism

    Metronidazole - causes massive proteinuria, nphs1 Knockdown - Loss of function

  • Phenotype

    Locomotor activity, Motor coordination,Fatigue, Stress, Anxiety

  • Biomarker

    Creatinine, Blood Urea Nitrogen, Albumin, Nephrin, Endothelin-1

  • Gene Expression Markers

    col1a1, TNF-α, IL-6, mmp9, casp3, nphs1,slc12a1

  • Physiology Changes

    Proteinuria, Edema, Osmoregulation, Hypertension, Lethargy

  • Histology Grading Endpoint

    Segmental scarring of glomeruli, Podocyte loss or depletion, Immune cell presence, Interstitial fibrosis

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