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Geographic Atrophy
Loss of Function

Geographic Atrophy

  • Genotype

    rpe1

  • Mechanism

    Loss of Function

  • Phenotype

    Visual acuity, Varying light response, Optokinetic response, Optomotor response, Exploratory behavior

  • Biomarker

    Rhodopsin, GFAP, VEGF-A, MMP-9

  • Gene Expression Markers

    best1, opn1lw, nrf2, cfh, casp3, apoe

  • Physiology Changes

    Electroretinography - a-wave amplitude, b-wave amplitude,RPE barrier integrity

  • Histology Grading Endpoint

    Loss of retinal pigment epithelium (RPE) cells, Thinning of outer nuclear layer (ONL), Loss or irregular pigmentation, Disorganized photoreceptor outer segments, Thinning of choroid

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