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Glioblastoma / Brain Tumors
GL261 - Toxic gain function and Loss of function, SB28 - loss of function

Glioblastoma / Brain Tumors

  • Genotype

    GL261, SB28

  • Mechanism

    GL261 - Toxic gain function and Loss of function, SB28 - loss of function

  • Phenotype

    Cognitive impairment, Motor coordination, Locomotor activity, Seizures, Weakness

  • Biomarker

    GFAP, IL 6, Nestin, S100β

  • Gene Expression Markers

    EGFR, mTOR , KI67/CCND1, MMP2, VEGF, IL-6/TNF-α, CD133, SOX2 

  • Physiology Changes

    Intracranial tumor growth, BBB disruption, Edema

  • Histology Grading Endpoint

    Hypercellularity, Diffuse infiltration into brain parenchyma, Microvascular proliferation, Necrosis

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