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Huntington's disease
Toxic gain function and partial loss of function

Huntington's disease

  • Genotype

    mHtt

  • Mechanism

    Toxic gain function and Partial loss of function

  • Phenotype

    Involuntary jerky movements, Spatial learning, Conditional Learning, Psychosis, Locomotor activity

  • Biomarker

    BDNF, Synaptophysin, GFAP, Iba-1

  • Gene Expression Markers

    DARPP32,DRD1 / DRD2, TNF, IL6

  • Physiology Changes

    EEG - Abnormal cortical rhythm, Seizure activity

  • Histology Grading Endpoint

    Thinning of cerebral cortex, Microglial activation and Neuronal shrinkage

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