Thyroxine induction - excess T4/T3 activates a negative feedback loop that suppresses the release of TRH and TSH from the pituitary gland
Hyperthyroidism
Genotype
Thyroxine induction
Mechanism
Thyroxine induction - excess T4/T3 activates a negative feedback loop that suppresses the release of TRH and TSH from the pituitary gland
Phenotype
Locomotor activity, Hyperactivity, Agitation, Anxiety, Depression, Motor coordination, Sleep disturbance, Cognitive impairment, Heat intolerance
Biomarker
Thyroxine, Thyroid stimulating hormone, Insulin, Triglycerides, Creatine kinase
Gene Expression Markers
Trh , Tshb , Thra, Thrb, Ucp1, Pgc1α, Glut4, Pck1
Physiology Changes
Body weight, Lean mass, Fat mass, Body temperature, Heart rate
Histology Grading Endpoint
Enlarged follicles filled with colloid, Hepatocyte hypertrophy, Reduced lipid droplets, Reduced TSH positive cells