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Hypertriglyceridemia
Loss of function

Hypertriglyceridemia

  • Genotype

    apop2 -/- and lpl -/-

  • Mechanism

    Loss of function

  • Phenotype

    Locomotor activity, Fatigue, Abnormal swimming, Anxiety, Response to external stimuli, Endurance

  • Biomarker

    Triglycerides, Total cholesterol, LDL, HDL, VLDL

  • Gene Expression Markers

    lpl, apoa2, apoc2, apoa5, pparα, cpt1a, acox1, srebp1, fasn, acc1, il1β, tnfα, nf-κb

  • Physiology Changes

    Hepatic steatosis, Oxidative stress, Hypertriglyceridemia, Liver enlargement

  • Histology Grading Endpoint

    Vacuolated hepatocytes, Foam cell formation, Lipid accumulation in vasculature, Inflammatory cell infiltration

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