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Hypothyroidism
Loss of Function

Hypothyroidism

  • Genotype

    Trhr1 KO

  • Mechanism

    Loss of Function

  • Phenotype

    Locomotor activity, Fatigue, Anxiety, Depression, Touch evoke response, Cognitive deficit, Cold intolerance

  • Biomarker

    Thyroxine, Thyroid stimulating hormone, Total cholesterol, Blood glucose

  • Gene Expression Markers

    Trhr1 , Trh , Tshb, Tpo, Tg, NIS, Bdnf, Syn1

  • Physiology Changes

    Body weight, Lean mass, Fat mass, Body temperature, Heart rate

  • Histology Grading Endpoint

    Reduced follicular size, Reduced neuronal density, Increased lipid droplets, Increased colloid content

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