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Idiopathic Hypersomnia
Toxic gain function 

Idiopathic Hypersomnia

  • Genotype

    Sik3

  • Mechanism

    Toxic gain function 

  • Phenotype

    Total sleep time, Sleep inertia, Locomotor activity, Cognitive impairment, Anxiety, Touch evoke response

  • Biomarker

    Leptin, Ghrelin, Melatonin, IL-6, Adenosine

  • Gene Expression Markers

    HOMER1a, GAD1, GRIN1, ADORA1, CRH

  • Physiology Changes

    EEG - NREM sleep periods, Transition from wake to NREM sleep, Circadian EEG rhythm

  • Histology Grading Endpoint

    Less neuronal loss, Synaptic density, Changes in cortex structure

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