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Idiopathic Pulmonary Fibrosis
Bleomycin Induction - causes patchy parenchymal inflammation followed by fibrosis

Idiopathic Pulmonary Fibrosis

  • Genotype

    Bleomycin Induction

  • Mechanism

    Bleomycin Induction - causes patchy parenchymal inflammation followed by fibrosis

  • Phenotype

    Locomotor activity, Fatigue, Anxiety

  • Biomarker

    Fibronectin, PDGF, Surfactant proteins, VEGF-A, SAA, CRP

  • Gene Expression Markers

    col1a1, acta2, TNF-α, IL-6, cdh1, nrf2, sod1, casp3, hif1a, 

  • Physiology Changes

    Respiratory rate, ROS production, Acute inflammation

  • Histology Grading Endpoint

    Dense fibrotic regions, Presence of fibroblast, Increased α-SMA-positive cells, Excess extracellular matrix accumulation, Cystic airspaces

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