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Kleine-Levin Syndrome
Loss of Function

Kleine-Levin Syndrome

  • Genotype

    TRANK1 KO

  • Mechanism

    Loss of Function

  • Phenotype

    Locomotor activity, Sleep time, Sleep bout, Circadian rhythm, Social isolation, Cognitive impairment, Feeding behavior, Anxiety

  • Biomarker

    Cortisol, ACTH, Orexin, BDNF, Dopamine, Ghrelin

  • Gene Expression Markers

    clock, bmal1, per1, gad1, gad2, TH, DRD2, IL 6

  • Physiology Changes

    EEG - NREM sleep changes, Delta power analysis, REM sleep latency, Circadian rhythm analysis

  • Histology Grading Endpoint

    Extensive neuronal loss,Neuroinflammation, Broad disruption of neural circuits, Microglial activation, Cortical alterations

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