SNCA - Toxic gain function
Lewy body dementia
Genotype
SNCA
Mechanism
Toxic gain function
Phenotype
Motor Coordination, Sleep disturbances, Locomotor activity, Anxiety, Novel object recognition, Spatial learning
Biomarker
α-Synuclein, Phosphorylated α-Synuclein, GFAP
Gene Expression Markers
SNCA, TH, SLC6A3 (DAT), SYP, BECN1
Physiology Changes
EEG - Long Term potentiation amplitude (LTP) and EPSP slope
Histology Grading Endpoint
Lewy body formation and Neuronal loss